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Pamela Sklar, M.D., Ph.D.
Address:
Massachusetts General Hospital
Harvard Medical School
Simches Research Building,
185 Cambridge Street,
Boston, MA 02114
Phone Number: (617) 726-0475
Email: sklar@chgr.mgh.harvard.edu
Adminstrative contact: Jarred Knapp
Phone: (617) 643-3667
jknapp@partners.org
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Dr. Sklar completed clinical training in Psychiatry at Columbia Presbyterian Hospital and the New York State Psychiatric Institute in Manhattan and research training in the laboratories of Solomon Snyder (Johns Hopkins Medical School) and Richard Axel (Columbia University). Her primary laboratory is located in the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) in the Center for Human Genetic Research at Massachusetts General Hospital, where she is an associate professor of psychiatry and the associate director of the PNGU. Dr. Sklar is also an associate member of the Broad Institute.
Dr. Sklar is a neuroscientist, human geneticist and clinical psychiatrist investigating the genetic causes of psychiatric disorders, including schizophrenia and bipolar disorder. A major focus of her work is to identify susceptibility genes for psychiatric diseases by applying tools developed for understanding and characterizing human sequence variation. Additional work utilizes translational approaches including mouse models of human behaviors as alternate routes to disease genes as well as identifying the specific biological consequences of disease-causing variation. Working closely with PNGU statistical geneticist Shaun Purcell, there is also a strong focus on the development of novel methods for genetic analyses including gene-based and pathway based tests, imputation, segmental sharing (rare variants), epistasis, predictive modeling, and exploration of the genetic factors contributing to treatment response in particular as applied to bipolar disorder and schizophrenia.
Currently, Dr. Sklar’s group is part of a several large consortia of researchers exploring the genetics of schizophrenia and bipolar disorder. Genome-wide association analyses in bipolar disorder in over 4000 cases and 6000 controls have identified several new genes for bipolar disorder.
Dr. Sklar is also a senior associate member of the Broad Institute, as well as a founding member of the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard and where she serves as director of genetics.
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