Anxiety Disorders and Anxious Temperament
Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW , Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, Macintyre DJ, Maclean AW, St Clair D, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Nicol Ferrier I, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH; Wellcome Trust Case Control Consortium, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 2008 Aug 17. [Epub ahead of print].
Smoller JW and Faraone SV. Genetics of anxiety disorders: complexities and opportunities. Am J Med Genet C Semin Med Genet. 2008 May 15;148(2):85-8.
Smoller JW , Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, and Stein MB. Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry. 2008;65(3):298-308.
Smoller JW , Mark H. Pollack MH, Wassertheil-Smoller S, Jackson RD, Oberman A, Wong ND, Sheps D. Panic attacks and risk of incident cardiovascular events among post-menopausal women in the Women’s Health Initiative Observational Study. Archives of General Psychiatry Arch Gen Psychiatry. 2007;64(10):1153-1160.
Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW , Perlis R, Leboyer M, Delorme R, Chabane N, Rauch SL, Jenike MA, Pauls DL. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. Arch Gen Psychiatry 2007;64:209-215.
Smoller JW , Yamaki LH, Fagerness JA, Biederman J, Racette S, Laird NM, Kagan J, Snidman N, Faraone SV, Hirshfeld-Becker D, Tsuang MT, Slaugenhaupt SA, Rosenbaum JF, and Sklar P. The corticotropin releasing hormone gene and behavioral inhibition in children at risk for panic disorder. Biological Psychiatry 2005;57:1485-1492.
Koenen KC, Saxe G, Purcell S, Smoller JW , Bartholomew D, Miller A, Hall E, Kaplow J, Bosquet M, Moulton S, and Baldwin C. Polymorphisms in FKBP5 are associated with peri-traumatic dissociation in medically injured children. Mol Psychiatry, 2005 Dec;10(12):1058-9
Smoller JW , Rosenbaum JF, Biederman J, Kennedy J, Dai D, Racette S, Laird N, Kagan J, Snidman NC, Hirshfeld-Becker, D, Tsuang MT, Sklar PB, and Slaugenhaupt SA. Association of a genetic marker at the corticotropin releasing hormone locus with behavioral inhibition. Biological Psychiatry 2003;54:1376-1381
Smoller JW , Pollack MH, Wassertheil-Smoller S, Barton B, Hendrix SL, Jackson RD, Dicken T, Oberman A, and Sheps DS. Prevalence and correlates of panic attacks in post-menopausal women: Results from an ancillary study to the Women’s Health Initiative. Archives of Internal Medicine 2003;163:2041-2050.
Smoller JW , Acierno JS, Rosenbaum JF, Biederman J, Pollack MH, Meminger S, Pava J, Helbling L, White C, Bulzacchelli M, and Slaugenhaupt SA. Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2001;105:195-206.
Smoller JW , Rosenbaum JF, Biederman J, Susswein LS, Kennedy J, Kagan J, Snidman NC, Laird N, Tsuang MT, Faraone SV, Schwarz A, and Slaugenhaupt, SA. Genetic association analysis of behavioral inhibition using candidate loci from mouse models. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2001;105:226-235.
Smoller JW and Tsuang MT. Panic and phobic anxiety: defining phenotypes for genetic studies. American Journal of Psychiatry, 1998; 1152-1162.
Bipolar Disorder and Depression
Sullivan P, de Geus E, Willeen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Dohke M, Farmer A, Fava M, Gordon SD, He Q, Heath A, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery G, Muir WJ, Nolen W, Nöthen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW , Tzeng J-Y, van Dyck R, Verhage M, G. ZF, Martin NG, Wray NR, Booma DI, Penninx B. Genomewide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry In press.
Perlis RH, Holt D, Smoller JW , Blood A, Lee S, Kim BW, Lee MJ, Sun M, Makris M, Kennedy D, Rooney K, Dougherty D, Hoge R, Rosenbaum JF, Fava M, Gusella JF, Gasic G, and Breiter HC. A polymorphism near CREB1 is associated with differential aversion processing in the insula of healthy subjects. Arch Gen Psychiatry, 2008 Aug;65(8):882-892.
Sklar P, Smoller JW , Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PIW, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumensteil B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DM, McLean A, VanBeck M, McQullin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. Whole-genome association study of bipolar disorder. Molecular Psychiatry 2008 Jun;13(6):558-569.
Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki L, Fava M, and Smoller JW . Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. Biol Psychiatry. 2007 Sep 1;62(5):536-40.
Simon NM, Smoller JW , McNamara KL, Maser RS, Zalta AK, Pollack MH, Nierenberg AA, Fava M, Wong KK. Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry. 2006 Sep 1;60(5):432-5.
McQueen MB*, Devlin B*, Faraone SV*, Nimgaonkar VL*, Sklar P*, Smoller JW *, Abou Jamra R, Albus M, Bacanu S-A, Baron M, Barrett TB, Berretini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly M, DePaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Jou S-H, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, MacKinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JR, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi P, and Laird NM*. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence for susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet, 2005 Aug 15;77:582-595. *Principal members of the Meta-Analysis Working Group for the Genetic Determinants of Bipolar Disorder
Smoller JW and Finn CT. Family, twin and adoption studies of bipolar disorder. American Journal of Medical Genetics (Semin Med Genet), 2003;123C:48-58.
Attention Deficit Hyperactivity Disorder
Doyle AE, Ferreira, MAR, Sklar P, Lasky-Su, J, Petty C, Fusillo SJ, Seidman LJ, Willcutt EG, Smoller JW , Purcell S, Biederman J, and Faraone SV. Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: Suggestive linkage to 3q13. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 30 [Epub ahead of print]
Biederman J, Kim JW, Doyle AE, Mick E, Fagerness J, Smoller JW , Faraone SV. Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD. Am J Med Genet B Neuropsychiatr Genet., 2008 Oct 20. [Epub ahead of print]
Kim JW, Waldman ID, Faraone SV, Biederman J, Doyle AE, Purcell S, Arbeitman L, Fagerness J, Sklar P, and Smoller JW . Investigation of parent-of-origin effects in ADHD candidate genes. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144(6):776-80.
Smoller JW , Biederman J, Arbeitman L, Doyle AE, Fagerness J, Perlis RH, Sklar P, Faraone, SV. Association between the 5HT1B receptor gene and the inattentive subtype of ADHD. Biological Psychiatry, 2006 Mar 1;59(5):460-7.
Faraone SV, Perlis RH, Doyle AE, Smoller JW , Goralnick JJ, Holmgren MA and Sklar PB. Molecular genetics of attention deficit hyperactivity disorder. Biological Psychiatry 2005:57:1313-1323.
Genetic Epidemiology and Methods
Vansteelandt S, DeMeo DL, Su J, Smoller JW , Murphy AJ, McQueen M, Schneiter K, Celedon JC, Weiss ST, Silverman EK, and Lange C. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2007 Oct 26; [Epub ahead of print]
Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW , Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, and Altshuler D. Assessing the impact of population stratification on genetic association studies. Nature Genetics 2004;36:388-393.
Robins JM, Smoller JW , and Lunetta KL. On the validity of the TDT test in the presence of comorbidity and ascertainment bias. Genetic Epidemiology 2001;21:326-336.
Smoller JW , Lunetta KL, Robins J. Implications of comorbidity and ascertainment bias for identifying disease genes. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2000;96:817-822.
Wilcox MA, Smoller JW , Lunetta KL, Neuberg D. Using recursive partitioning for exploration and follow-up of linkage and association analyses. In: Goldin L et al.. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology 17(suppl 1);1999:385-390.
Pharmacogenetics
Perlis RH, Purcell S, Fagerness J, Trivedi MH, Fava M, Rush AJ, Smoller JW . Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: Association of TREK1 and treatment resistance in the STAR*D study. Neuropsychopharmacology. 2008 Feb 20; [Epub ahead of print]
Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, and Smoller JW . Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cAMP Response Element Binding Protein (CREB1) in the STAR*D study. Arch Gen Psychiatry 2007;64:689-697.
Perlis RH, Laje G, Smoller JW , Fava M, Rush AJ, and McMahon FJ. Genes of the glutamate but not serotonin system are associated with sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology, in press.
Clinical Applications
Smoller JW , Rosen-Sheidley B, and Tsuang MT (eds). Psychiatric Genetics: Applications in Clinical Practice. Washington, DC: American Psychiatric Publishing, Inc., 2008.
Finn CT and Smoller JW . Genetic counseling in psychiatry. Harv Rev Psychiatry. 2006 Mar-Apr;14(2):109-21.
Finn CT, Wilcox MA, Korf BR, Blacker DL, Racette SA, Sklar P, Smoller JW . Psychiatric genetics: a survey of psychiatrists’ knowledge, opinions and practice patterns. J Clin Psychiatry 2005;66:821-830.
