International Schizophrenia Consortium (ISC)
The International Schizophrenia Consortium (ISC) was
established to promote rapid progress towards the identification of
genetic causes underlying schizophrenia.
The ISC is comprised of investigators from the University of Aberdeen,
Trinity College Dublin, Cardiff University, the University of
Edinburgh, the University of Southern California, Massachusetts
General Hospital, the Broad Institute of Harvard and MIT, the
Karolinska Institutet, the University of North Carolina-Chapel Hill,
and University College London.
Research
We are currently engaged in a genome-wide survey of single nucleotide
polymorphisms (SNPs) and copy number variants (CNVs) in thousands of
individuals with and without schizophrenia.
Main ISC publications
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder, Nature 2009
| PubMed
- Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008 |
| PubMed
| Supplementary data
ISC in the news
Additional publications
- Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. Raychaudhuri et al, 2009. PLoS Genetics
| PubMed
- Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
Kirov et al, 2009. Human Molecular Genetics
| PubMed
Consortium sites and members
Stanley Center for Psychiatric Research and Broad Institute of MIT and Harvard
Shaun Purcell, Jennifer Stone, Kimberly Chambert, Douglas Ruderfer,
Edward Scolnick, Pamela Sklar
Cardiff University
Michael O'Donovan, George Kirov, Nick Craddock, Peter Holmans, Nigel
Williams, Lucy Georgieva, Ivan Nikolov, Nadine Norton, H Williams,
Draga Toncheva, Vihra Milanova, Michael Owen
Karolinska Institutet / University of North Carolina at Chapel Hill
Christina Hultman, Paul Lichtenstein, Emma Thelander, Patrick Sullivan
Massachusetts General Hospital
Jennifer Stone, Douglas Ruderfer, Shaun Purcell, Pamela Sklar
Trinity College Dublin
Derek Morris, Colm O'Dushlaine, Elaine Kenny, John Waddington, Michael Gill, Aiden Corvin
University College London
Andrew McQuillin, Khalid Choudhury, Susmita Datta, Jonathan Pimm,
Srinivasa Thirumalai, Vinay Puri, Robert Krasucki, Jacob Lawrence,
Digby Quested, Nicholas Bass, David Curtis, Hugh Gurling
University of Aberdeen
Caroline Crombie, Gillian Fraser, Noelle Kwan, Nicholas Walker, David
St. Clair
University of Edinburgh
Douglas Blackwood, Walter Muir, Kevin McGhee, Alan Maclean, Margaret Van Beck
Queensland Institute of Medical Research
Peter Visscher, Stuart Macgregor, Naomi Wray
University of Southern California
Michele T. Pato, Helena Medeiros, Frank Middleton, Celia Carvalho,
Christopher Morley, Ayman Fanous, David Conti, James Knowles, Carlos
Paz Ferreira, Antonio Macedo, M. Helena Azevedo, Carlos N. Pato
Last updated 3-July-2009